Liverpool booked their spot in the Champions League semi-finals after beating FC Porto 4-1 at the Estadio do Dragao.
The Reds held a 2-0 advantage from the first leg at Anfield and Sadio Mane, Mohamed Salah and Roberto Firmino all got on the scoresheet in Portugal while Virgil van Dijk also hit the back of the net.
All three players have now hit four goals each so far in the competition, elevating the trio into the top 25 scorers this season.
The Argentine now has an outrageous 10 goals in Europe so far this season, putting him two clear of nearest challenger Robert Lewandowski.
However, Bayern Munich were eliminated by Liverpool so the Pole will not have an opportunity to catch Messi.
Cristiano Ronaldo also has no chance to add to his six strikes after Juventus were knocked out at the hands of Ajax.
The Dutch side have been propelled to their first semi-final since 1997 by the goals of Dusan Tadic, with the Serbian having notched six already
Liverpool have no players among the top 25 Champions League scorers this season (Image: GETTY)
Cristiano Ronaldo and Juventus were knocked out by Ajax in the quarter-finals (Image: GETTY)
Meanwhile, Manchester City frontman Sergio Aguero has scored six times after finding the back of the net in a thrilling second leg against Tottenham.
Raheem Sterling also bagged a double in the 4-3 win for Pep Guardiola's side, although City were dumped out on away goals.
Leroy Sane and Gabriel Jesus both have four strikes apiece while David Silva has three, showing the prolific form City had been in this season.
Harry Kane has five goals but is potentially out for the season with an ankle injury and is not expected to play in the next round.
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Manchester City have been prolific in the competition so far (Image: GETTY)
Champions League top scorers 2018/19
Philippe Coutinho (Barcelona) – 3 goals, 2 assists
Jesus Manuel Corona (FC Porto) – 3 goals, 2 assists
Nabil Fekir (Lyon) – 3 goals, 2 assists
Moraes (Shakhtar Donetsk) – 3 goals, 2 assists
David Silva (Manchester City) – 3 goals, 2 assists