Arsenal are still expected to dispatch the Seasiders, but London rivals Chelsea face a stern test against Nottingham Forest at Stamford Bridge.
Maurizio Sarri’s men have struggled to dominate home games in recent weeks after losing to Leicester and being held to a goalless draw with Southampton.
They had to wait until the 84th minute for Eden Hazard to strike the winner against Bournemouth in their Carabao Cup match last month.
Forest sit seventh in the Championship and will take plenty of heart from their 4-2 victory over table-toppers Leeds on New Year’s Day.
There are plenty of big ties being played around the country today and Express Sport has predicted the result for each of them – do you agree?
FA Cup fixtures: Premier League teams are gearing up to enter the competition (Image: Getty Images)
FA Cup predictions
12:30pm
AFC Bournemouth 1–1 Brighton
Burnley 1–0 Barnsley
Manchester United 3–1 Reading
Sheffield Wednesday 1–1 Luton
Shrewsbury 0–2 Stoke
West Bromwich Albion 2–0 Wigan
West Ham 2–1 Birmingham
FA Cup fixtures: United will hope to get the job done at Old Trafford (Image: Getty Images)
Invalid email
We use your sign-up to provide content in ways you've consented to and to improve our understanding of you. This may include adverts from us and 3rd parties based on our understanding. You can unsubscribe at any time. Read our Privacy Policy
3:00pm
Accrington Stanley 0–0 Ipswich
Aston Villa 2–1 Swansea
Bolton 0–1 Walsall
Brentford 2–1 Oxford
Chelsea 1–2 Nottingham Forest
Derby 2–3 Southampton
Everton 3–0 Lincoln
Fleetwood 2–0 AFC Wimbledon
Gillingham 1–3 Cardiff
Middlesbrough 1–1 Peterborough
FA Cup fixtures: VAR is in action for the Third Round (Image: Getty Images)