Steve Bruce’s side are charging up the Championship table thanks to a run of six wins in eight games, but the Owls visit to Villa Park will be their third game in six days.
Wednesday, who reached the play-offs in the last two seasons, have underwhelmed this term.
But Championship pundit Prutton reckons Carlos Carvalhal’s side could make the most of tiredness in the Villa ranks.
“Sheffield Wednesday got back to winning ways in midweek but every time they do get a victory it seems to be followed quickly by another poor run, and that's why they find themselves in mid-table at the start of November.
“Aston Villa, meanwhile, will be content with their draw at Birmingham and got a great win at Preston on Wednesday night, but it's been a tough week and I feel like this will be a [2-2] draw.
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