Higuain, who was linked with Arsenal before joining Napoli in 2013 and once again this summer, says the former Manchester United star is egotistical.
The Argentina international also claims he is nothing like Lionel Messi, who is generally vying with Ronaldo for the title of the world's best player.
"He has a lot of ego," Higuain said.
"If you don't say he's the best, he's not your friend.
GETTY
Cristiano Ronaldo and Gonzalo Higuain played together at Real Madrid
"Cristiano thinks he's the best but he's over-rated.
"I've shared a dressing room with Messi and one is nothing like the other."
Higuain, 27, is still persistently linked with a move to the Gunners but insists he has resigned previous links to the past.
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Higuain claims Ronaldo is nothing like Lionel Messi
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