Pulisic has had an injury-hit season after starting the campaign still recovering from a hamstring injury picked up in the FA Cup final defeat to Arsenal.
The American has been sidelined since October with a recurrence of the hamstring issue but has resumed training in the past week.
Kai Havertz is also available to Lampard after he made his return to action on Tuesday after a spell in quarantine for coronavirus.
"Team news-wise, we are as we were really," Lampard said at his pre-match press conference.
Chelsea attacking midfielder Christian Pulisic (Image: GETTY)
"Christian Pulisic is back in contention for the game after working on his fitness.
"Whether Christian is ready to start is another question, as it is hard to gauge match fitness when you’ve only been training but he is ready and he is in contention.
"Kai Havertz played some minutes against Rennes the other day following his time out and it’s more just checking on his potential for match fitness, but overall we are in pretty good shape."
In defence, Thiago Silva will start after missing last weekend's Premier League win over Newcastle due to returning late from international duty.
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