"It is a derby and all the times we play against United they are special games and players do their best."
Liverpool have given the defending champions a run for their money this season.
Jurgen Klopp's side moved two points ahead at the top of the table following their win over Cardiff on Sunday, although the Reds had played a game more than City.
But winger Bernardo Silva is determined for City to keep the Premier League title race in their own hands, starting with victory over rivals United.
"It's another massive game that we know we need to win as Liverpool will probably win all the games they have left in the Premier League," Silva said.
"We only depend on ourselves but they depend on us and we want to try to keep it that way."
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Man City: Foden should leave if not played enough says Mills
Man City must hold off the challenge of Liverpool (Image: GETTY)