Sergio Aguero struggled to make an impact against Barcelona [GETTY]
Aguero was replaced at half-time at the Nou Camp as City slipped to a 2-1 defeat and exited the Champions League.
And to add insult to injury, the club's top scorer Aguero suffered another hamstring problem and will require a scan.
The Argentine marksman is almost definitely out of City's clash with Hull on Saturday, but could miss their Premier League meeting with Fulham and visits to rivals United and Arsenal later this month.
Aguero picked up an injury during a clash with Lionel Messi [EPA]
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"I felt a twinge in the leg early on after a challenge with Messi," Aguero said.
"I carried on with it for the rest of the half but at half-time we decided not to risk it."
Aguero completed just one pass against Barcelona, with his early touch coming from kick-off.
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