Betis shocked Real Madrid as Antonio Sanabria scored a 94th-minute winner to secure their first win at the Bernabeu for 19 years.
The hosts dominated throughout but Real were wasteful with no-one able to capitalise on the 27 efforts on goal.
The defeat leaves Zinedine Zidane’s side seven points adrift of leaders Barcelona.
And many fans have been taking to Twitter to slam Real after the defeat destroyed many supporter’s accumulators.
Click through the gallery above to see some of the best tweets!
GETTY
Real Madrid suffered a shocking defeat to Real Betis and fans are furious
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