Lindelof joined Manchester United in a £30million deal in the summer.
The 23-year-old centre-back made his competitive debut in the 2-1 Super Cup defeat to Real Madrid last month but failed to impress.
He’s yet to feature in United’s opening four Premier League games, but did return to the starting line up for the 3-0 Champions League win over Basel on Tuesday night.
And after an impressive performance in their Group A opener, Mourinho admits he would consider the Sweden international in the Premier League.
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Jose Mourinho gives Victor Lindelof Premier League hope
If Lindelof has to play in the Premier League I have no problem
Jose Mourinho
The United manager believes the former Benfica man is his best defender at attacking midfields.
"If Lindelof has to play in the Premier League I have no problem with that," Mourinho said.
"Can he make a mistake that comes with adapting to the nature of the Premier League? I think he can.
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"But the nature of the Premier League is also changing and we need defenders who can play, who can come into the midfield bringing the ball.
“Because it's becoming really defensive and we're going to face many teams with five in the back and two or three in front.
"Victor of all our defenders is probably the one to bring more quality when he attacks the midfield."