Mourinho is already without the likes of Chris Smalling, Phil Jones, Marcos Rojo, Juan Mata and Zlatan Ibrahimovic, all out through injury.
And now Pogba will be assessed ahead of United's trip to Manchester City, with Mourinho unsure if his withdrawal at Turf Moor was the result of an injury or fatigue.
United can leapfrog their cross-town rivals and propel themselves into the top four with a win at the Etihad on Thursday (8pm).
"I don't know - dead (on his feet), he is for sure," Mourinho said of the France international.
GETTY
Paul Pogba was forced off against Burnley
GETTY
Jose Mourinho and Pep Guardiola go head to head at the Etihad
Invalid email
We use your sign-up to provide content in ways you've consented to and to improve our understanding of you. This may include adverts from us and 3rd parties based on our understanding. You can unsubscribe at any time. Read our Privacy Policy
"If he is injured or it's just super-accumulation of fatigue in the muscles, I don't know.
"But if he cannot play Thursday, then he cannot play Thursday. We play another one and we don't cry."