Man Utd boss Louis van Gaal will have to cope without Bastian Schweinsteiger
Manager Louis van Gaal called the injury a "big blow", hinting his season could be over, making him a major doubt for the European Championships in the summer.
Ander Herrera and Ashley Young could be involved in the Sunday afternoon clash after recovering from injuries.
For Everton, John Stones is fit and available after taking part in training on Friday.
Kevin Mirallas returns from suspension but Gareth Barry is out as he serves the final match of a two-game ban.
Manchester United v Everton - Premier League match preview
Manchester United provisional squad: De Gea, Romero, Darmian, Riley, Rojo, Varela, Valencia, McNair, Borthwick-Jackson, Williams, Fosu-Mensah, Blind, Smalling, Schneiderlin, Herrera, Fellaini, Carrick, Weir, Mata, Young, Lingard, Depay, Martial, Rashford.
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