Arsene Wenger will be reshuffling his midfield at the end of the season with Mathieu Flamini, Mikel Arteta and Tomas Rosicky all expected to leave the club.
And now Spanish newspaper Marca are reporting that with Saturday's defeat to Atletico Madrid all but ending Los Blancos' hopes of a league title, they are ready to start arranging the transfers of Isco and Rodriguez.
Express Sport understands that Rodriguez is on a shortlist of players at Manchester United as they seek to recover from a difficult season at Old Trafford with a big-money marquee signing.
Despite spending nearly £250m at the club, Louis van Gaal is yet to deliver a trophy and Jose Mourinho is expected to take over if he misses out on Champions League qualification.
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And if Van Gaal does miss out on a top-four finish, United executive vice-chairman Ed Woodward is ready to hand the Portuguese boss the reins and yet more cash in search of a first Premier League title since Sir Alex Ferguson retired.
United have already held preliminary talks with super-agent Jorge Mendes, who represents Rodriguez, and the transfer fee is expected to be around £63m.
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