The Argentine boss confirmed Ryan Mason, Nabil Bentaleb and Mousa Dembele are all sidelined for the tie.
"Mousa, Ryan and Nabil are still out," reported Mauricio after training on Tuesday. "Their progression is very good, they are close to being back with the squad but not for Wednesday, unlucky for them and for us."
Spurs have a busy schedule of fixtures coming up with Manchester City this weekend before a Europa League trip to Monaco next week.
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