Cech makes his first start of the season under Jose Mourinho, with Thibaut Courtois dropping to the bench.
Kurt Zouma makes his Chelsea debut in defence, with Filipe Luis also returning to the team.
Nathan Ake partners Jon Obi Mikel in midfielder, with Loic Remy getting the nod in attack ahead of Didier Drogba.
Oscar and Andre Schurrle are back in the starting XI and are joined by Mohamed Salah, who will be hoping to impress in order to get more first team chances.
Jermain Beckford leads the line for the Trotters, although ex-Liverpool star Jay Spearing has to settle for a place on the bench.
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