Frank Lampard will be hoping he can replicate last season's win at the Emirates Stadium when he takes his side to north London this evening. The Blues boss enjoyed a memorable afternoon as late goals from Jorginho and Tammy Abraham snatched all three points as Chelsea trailed with just seven minutes of normal time to play.
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It means Emerson Palmieri should get a rare start with Marcos Alonso still banished from Lampard's first team set up due to a disciplinary problem.
Captain Cesar Azpilicueta will keep his place after starting in place of James against the Hammers.
Hakim Ziyech will also been absent, despite being tipped for a return against the Gunners.
The Moroccan has not played since he pulled up with a hamstring problem in the 3-1 win over Leeds earlier this month.
"It's a muscle injury so we need to wait for it to recover," Lampard said on Wednesday.
Chelsea team news: The Blues will be without Reece James and Ben Chilwell (Image: GETTY)
"Not a long-term concern and we hope to have him back in a week or so.
"That's football when players are playing every two or three days."
Callum Hudson-Odoi is back in training but this match is likely to come too soon for him as well.
Mateo Kovacic may come back into midfield ahead of Jorginho while Timo Werner can count himself lucky if he keeps his place in attack, due to his lack of form.
Expected Chelsea XI vs Arsenal (4-3-3): Mendy; Palmieri, Thiago Silva, Zouma, Azpilicueta; Kante, Kovacic, Mount; Pulisic, Abraham, Werner.