Liverpool's main man will need to step up due to the potential absence of Sadio Mane who is reportedly struggling with an injury.
Raheem Sterling's emergence – and high price tag – means FPL bosses are likely to be divided between the pair. Salah should enjoy a good night in Burnley.
Harry Kane (Tottenham) vs Southampton
Kane has bagged three goal in his last four games, and as Sunday proved, he can still find the net when his team is outperformed.
He's one of the toughest players to write off, and is primed for a big weekend against managerless Southampton.
Fantasy Premier League tips: Harry Kane is clicking into gear (Image: Getty Images)
Pierre-Emerick Aubameyang (Arsenal) vs Manchester United
The Premier League's top scorer has stormed into top form over the last month with a string of big goals.
United can be unpredictable, but Aubameyang has proven he can score against anyone.
Felipe Anderson (West Ham) vs Cardiff
This week's differential option comes in the form of West Ham's big-money summer signing.
Anderson has stepped up his game in recent weeks and looks like a real contender to grab points in the coming weeks with a favourable fixture list.
Fantasy Premier League tips: Raheem Sterling has been in rampant form (Image: Getty Images)
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TOP CHOICE – Raheem Sterling (Manchester City) vs Watford
Sterling is in the type of form that makes it incredibly tough to select any other player.
He may seem like a blatantly obvious candidate for the captaincy, but that's for good reason.
City's main man could torment the Watford backline, and could make you look silly if you opt for anyone else.