Fellow striker Romelu Lukaku is also currently sidelined with a muscle injury and was left out of the squad that travelled to Turin.
Sanchez had been deputising for the out-of-form attacker, who hasn’t scored in his past nine appearances.
However, with both Sanchez and Lukaku struggling an opportunity could be handed to Marcus Rashford.
The 20-year-old had been used primarily as a substitute this season but could spearhead the United attack if necessary.
Man Utd team news: The Chilean was forced off with a thigh problem against Juventus (Image: REUTERS)
The extent of Sanchez’s injury is as yet unclear, but Juan Mata is most likely to be deployed on the right flank if Rashford is given the nod up top.
Anthony Martial should continue on the left flank after bagging five goals in his last four games while Ander Herrera is expected to continue in midfield.
The Spaniard impressed last weekend against Bournemouth and was rewarded with a start against Juventus, helping provide more balance to the Red Devils midfield than summer signing Fred.
Eric Bailly and Antonio Valencia are still out of favour at Old Trafford, meaning Ashley Young should start at right-back alongside Chris Smalling and Victor Lindelof.
Man Utd team news: Is this how Jose Mourinho's side will line up against Manchester City? (Image: buildlineup.com)
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Manchester United predicted line-up vs Manchester City