That means if they remain ahead by that many points by the time the El Clasico comes around on May 6 then they will already be crowned champions.
And with that Ronaldo would have to form a guard of honour for Messi and his team-mates as they take to the pitch.
Diario Gol add that the 33-year-old is also worried of Barcelona’s dominance in the Champions League.
The striker apparently fears that only Manchester City would be able to stop Ernesto Valverde’s side but it looks likely Messi will help the Catalan club secure the prestigious trophy.
Ronaldo arrives in London ahead of Nike launch
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Messi and Ronaldo have won five Ballon d'Ors each.
To make matters worse, by winning the league title and Champions League Messi would be likely to claim the Ballon d’Or at the end of the year.
Finally, because Real are still battling for the Champions League places in the league, Ronaldo thinks he will have to give his maximum all the way to the end of the season, which could burn him out for the World Cup.
On the other hand, Messi could be rested for the final few matches and head to Russia fresh.