Zlatan Ibrahimovic makes his first appearance as a United player at Old Trafford following his goalscoring debut against Galatasaray on Saturday.
And there are two changes from the side which beat the Turkish side with Michael Carrick and Jesse Lingard coming in for Henrikh Mkhitaryan and Morgan Schneiderlin.
For Everton, Romelu Lukaku and John Stones are named in the starting eleven by Ronald Koeman despite intense speculation surrounding their futures.
Summer signing Maarten Stekelenburg starts in goal but Idrissa Gueye is not in the squad.
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