Wayne Rooney (left) has been given the all clear to face Saints
The 29-year-old sat out the 2-1 win over Stoke on Tuesday after picking up a knee injury when he collided into an advertising board during his side's 3-0 victory over Hull last Saturday.
Rooney was sent off for a scan and Louis van Gaal was initially cautious over the extent of the injury.
But according to reports, Rooney has been given the all-clear and is expected to be in contention to face Southampton.
Wayne Rooney Player Profile
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Rooney it is thought is already eyeing a return to training and is hoping to be named in Van Gaal's starting line up for the visit to the St Mary's Stadium next Monday (8pm).
United will be looking to close the gap on title chasers Chelsea and Manchester City with victory.
Van Gaal's side will go into the game in a rich vein of form, having chalked up four wins on the trot in the league.