Ramsey made his return from injury in the 2-1 win over Anderlecht in midweek, but drops to the bench against the Black Cats.
Alex Oxlade-Chamberlain starts in midfield in the Welshman's place.
Wojciech Szczesny comes back in for rookie Emiliano Martinez after his Champions League suspension, while Mikel Arteta replaces the banned Jack Wilshere.
Theo Walcott is not fit enough to start but takes a place on the bench.
Sunderland make two changes from the side that were thrashed 8-0 by Southampton last time out.
Aaron Ramsey drops to the bench for Arsenal[REUTERS]
Adam Johnson and Jack Rodwell come in for Connor Wickham and Jordi Gomez.
New boy Anthony Reveillere is on the bench for the hosts.
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