Manchester United v West Ham - Premier League Preview
Teenage defender Paddy McNair could be thrown into the deep end with Tyler Blackett (suspended), Jonny Evans (ankle), Chris Smalling (thigh) and Phil Jones (hamstring).
With Marcos Rojo United's only recognised fit centre half, Luke Shaw is poised to make his full first team debut.
Ashley Young (groin), Michael Carrick (ankle), Jesse Lingard (knee) and Marouane Fellaini (ankle) are unavailable.
Meanwhile, West Ham will be without Cheikhou Kouyate, who has been ruled out with a groin injury.
The Senegal international picked up the injury in the 3-1 win over Liverpool last weekend and could be sidelined for up to six weeks.
Manchester United provisional squad: De Gea, Lindegaard, Amos, Rafael, Valencia, Shaw, Rojo, McNair, Vermijl, Janko, Pereira, Blind, Herrera, Fletcher, Anderson, Mata, Januzaj, Di Maria, Rooney, Falcao, Van Persie, W Keane
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