The Gunners cannot qualify for next season's Champions League while their hopes of Europa League qualification are slim as they sit four points behind seventh place with three games remaining.
An alternative route into Europe exists if they can win the FA Cup and they meet Manchester City in Saturday's semi-final at Wembley.
As a result, Arteta could rest a host of players with one eye on the clash against his old tutor Pep Guardiola.
Speaking ahead of the Liverpool clash, Arteta hinted at changes.
"We have to go game by game, today we will know more as well about how the players have recovered," he said.
"Obviously some players have had huge demands since we rejoined the season and have played a lot of minutes, and you can see that recovery-wise with the schedule that we have been given by the Premier League, to play every two and a half days, but we will asses them today and tomorrow and put the players on the pitch who are in the best possible condition to compete and try to win the game again."
He added: "We played 11 games and we only had the advantage in one, which was against Spurs. In the rest, the other teams had at least 24/36/48 hours more than us. But look at the boys, they keep going, they go full gas.
"It doesn't matter and we will do it again. We cannot complain because it doesn't matter. They're not going to change it. The fixtures are already there, so we will keep going and try our best."
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Arsenal's predicted line up to face Liverpool (Image: GETTY)
Emiliano Martinez will continue between the sticks in front of a back-three that is likely to see Rob Holding given a run out in place of Sead Kolasinac, who blundered for Tottenham's equaliser in Sunday's derby.
Dani Ceballos could be given a breather ahead of the trip to Wembley so Joe Willock could be given a chance to partner Granit Xhaka in the engine room.
Cedric Soares is likely to start in place of Hector Bellerin at right-back.
The final change is likely to see Pierre-Emerick Aubameyang given a rest so Bukayo Saka should start after being named on the bench against Spurs.
Arsenal Predicted XI vs Liverpool: Martinez; Mustafi, Luiz, Holding; Soares, Willock, Xhaka, Tierney; Pepe, Lacazette, Saka
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