Claudio Bravo was brought on in that match though was sent off with Kyle Walker ending the game between the posts.
But Guardiola is confident that Bravo will perform well up against the likes of Mohamed Salah, Roberto Firmino and Sadio Mane.
The boss said: "He is an exceptional goalkeeper. He is an international goalkeeper. I have no doubts.
"Why shouldn't I be confident about my players? I see him every day in training. We won't lose because of Claudio.
Man City team news: Predicted 4-3-3 line up vs Liverpool – Guardiola changes (Image: GETTY/buildlineup.com)
Manchester City goalkeeper Ederson will not play against Liverpool (Image: GETTY)
Claudio Bravo is set to start for Manchester City against Liverpool (Image: GETTY)
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"The red card the other day was because we lost the ball. Respect the guy. He is a top keeper."
Joao Cancelo has impressed at right-back this season and is likely to start over Walker.
Fernandinho will fill in at centre-back alongside John Stones with Benjamin Mendy likely to start on the left side of defence.
David Silva is out injured meaning Bernardo Silva and Ilkay Gundogan could be given the nod in midfield.
Riyad Mahrez missed a last-gasp penalty at Anfield last season but could be given a chance to redeem himself with Raheem Sterling and Sergio Aguero joining him in attack.