Pochettino and Spurs hadn’t been active in the transfer window since January 2018 when they signed Lucas Moura.
Ndombele’s transfer will greatly please Tottenham fans who have waited 18 months to see their club make a signing.
And now there are just minor details to be ironed out, according to Italian football journalist Gianluca Di Marzio.
The 22-year-old has quickly become one of the most formidable midfielders in the world and will be seen as a long-term replacement for Moussa Dembele, who left in January.
Tottenham agree £65m deal for Tanguy Ndombele: Lyon star set for medical (Image: GETTY)
Tottenham agree £65m deal for Tanguy Ndombele: Lyon star set for medical (Image: GETTY)
Lyon club president Jean-Michel Aulas spoke about his player’s impending exit earlier this week but noted nothing was confirmed just yet.
“He is seeking a departure,” said Aulas.
“Nothing is done but the door may be open.”
Pochettino had seemingly previously threatened to quit Tottenham if a clear transfer plan had not been laid out for him by chairman Daniel Levy.
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Tottenham agree £65m deal for Tanguy Ndombele: Lyon star set for medical (Image: GETTY)
But their first big move of the summer looks set to go ahead - a move which will see Ndombele become Spurs’ most expensive transfer ever.
The club are awaiting the outcome of Christian Eriksen's big transfer decision, with the Dane keen on leaving Spurs in favour of a move to Real Madrid.
With just a year left on Eriksen's contract, they may have no option but to sell this summer, or they risk losing him for free in 2020.
Ndombele is known across Europe as a highly-astute midfield destroyer with a big physical presence. The 22-year-old takes up a more defensive role and was one of Ligue 1's best players last season.