United have the perfect opportunity to bounce back with Manchester City visiting Old Trafford, although a number of players are likely to drop out after their abject displays at the weekend.
Luke Shaw is available after a two-game domestic suspension and will return at left-back in place of Diogo Dalot.
Ashley Young was left on the bench last time out but came on at half-time and should start from the off here due to Phil Jones’ injury.
The former England international will slot in at right-back as Victor Lindelof returns to central defence alongside Chris Smalling.
Further forward, Fred is in danger of missing out if Ander Herrera is passed fit while Anthony Martial and Romelu Lukaku disappointed against the Toffees.
Jesse Lingard and Juan Mata are in contention to start while Alexis Sanchez is also available and could partner Rashford in attack if Solskjaer goes on the attack.
Man Utd team news: Ole Gunnar Solskjaer could make several changes against Man City (Image: GETTY•buildlineup.com)
Eric Bailly and Antonio Valencia remain injury doubts but are not expected to feature in any case as United look to end a poor run of form that has seen them lose six of their last eight matches in all competitions.
Speaking in his pre-match press conference about Shaw’s return, Solskjaer said: “He’s disappointed that he’s missed the three games that he has.
“He knows he has to improve on that. Some of his yellow cards weren’t yellow cards but some of them are his fault where he’s taken the easy option. We’ve spoken about that.
“It’ll be great to have him back because, both defensively and in attack, he’s been one of our best players.”
Man Utd team news: Is this how the Red Devils will line up against Man City? (Image: buildlineup.com)
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Manchester United predicted line-up vs Manchester City – Premier League