And with the advantage of being at home in the first round, the Reds will be looking to make the most of the clash.
The Merseyside team will be challenging the visiting side with key players such as Sadio Mane and Virgil van Dijk, both proven valuable in the round of 16.
But while Liverpool are favourites ahead of the quarter-finals tonight, Porto will be a tough challenge for the Merseyside team and should not be underestimated.
Liverpool vs FC Porto: Liverpool will welcome Porto to Anfield tonight (Image: GETTY)
Porto overturned a 2-1 first leg deficit to beat Roma 4-3 on aggregate thanks to a dramatic extra time penalty from Alex Telles in the round of 16.
The Portuguese team also have plenty of football veterans, with Iker Casillas’ leadership to be the key to a successful game for Porto.
In the last Champions League round at Anfield, Liverpool saw a goalless draw against Bayern Munich, before beating the German side 3-1 away in the second leg.
Jurgen Klopp will be keen for his men to get off to a fast start in the tie, avoiding a similar situation to the thriller away in the second leg of the last round.
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Liverpool vs FC Porto: Porto have arrived on Merseyside (Image: GETTY)
Liverpool vs FC Porto TV channel
The Liverpool vs FC Porto match will be shown live on BT Sport 3.
The clash will kick off at 8pm, with live coverage starting from 7.15pm.
If you don’t have access to BT Sport but a BT broadband customer, you can add it to your existing contract for £6 per month.
For new customers, broadband and BT TV packages start at £35.99 per month.
Liverpool vs FC Porto: Liverpool's training session ahead on tonight's Champions League clash (Image: GETTY)
Predicted line-ups
Liverpool
Alisson; Alexander-Arnold, Matip, Van Dijk, Milner; Henderson, Fabinho, Wijnaldum; Salah, Firmino, Mane