I’m worried every week when they’re fit and not suspended when you see some of their antics defensively
Charlie Nicholas on the Arsenal defence
Mustafi is also struggling with a hamstring injury and is a doubt for the Carabao Cup quarter-final against Tottenham next Wednesday.
Rob Holding will miss the rest of the campaign after suffering a long-term knee injury, with Konstantinos Mavropanos also yet to feature this season due to a groin problem.
That leaves Laurent Koscielny as the only available central defender - a player who has only played once since rupturing his Achilles back in May.
Nicholas was asked if he was worried about the Arsenal defence for the trip to Southampton with Sokratis and Mustafi unavailable.
Arsenal news: Shkodran Mustafi and Sokratis will miss the trip to Southampton due to suspension (Image: GETTY)
Arsenal news: Sokratis joined from Borussia Dortmund in the summer (Image: GETTY)
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Arsenal news: Shkodran Mustafi is also struggling with a hamstring injury (Image: GETTY)
But he admitted he is never comfortable even when the duo are in the team.
“I’m worried every week when they’re fit and not suspended when you see some of their antics defensively,” Nicholas said.