The Serbian international missed Saturday’s draw with Wolves having seen red in the win at Watford.
Speaking to MUTV, Mourinho confirmed Herrera would return: “Ander is ready.”
Diego Dalot impressed on his debut in the Champions League win at Young Boys.
This will be the first time the young full-back has played for the senior team at Old Trafford.
Man Utd team news: Herrera has been out since the win over Burnley (Image: GETTY)
“He has played there but with an empty stadium. He played in the Under-23s, now he plays in the first team,” Mourinho added.
“Obviously people liked what they saw in the match against Young Boys.
“This is an English competition, the different salt and pepper that English competitions have and I think it is good for him, for his development, for him to be ready for the top flight as soon as possible.“
Marcos Rojo is the only United player who will miss out through injury.
We use your sign-up to provide content in ways you've consented to and to improve our understanding of you. This may include adverts from us and 3rd parties based on our understanding. You can unsubscribe at any time. Read our Privacy Policy
Man Utd team news: Rashford will serve the last match of his suspension (Image: GETTY)
Marcus Rashford will serve the last match of his suspension after his red card vs Burnley.
The match will see Derby boss Frank Lampard try and outwit his former coach Mourinho.
The pair enjoyed plenty of success together at Chelsea and Lampard revealed after retiring that the Portuguese was the best manager he’s ever played for.