Barcelona star Dembele has emerged as a target for Arsenal and Liverpool ahead of the summer transfer window, with the France international failing to click with Messi, Luis Suarez and Co.
The player joined from Borussia Dortmund back in the summer for £120million but, following the arrival of Philippe Coutinho in January, has found game time at the Nou Camp hard to come by.
And Spanish outlet Don Balon claim Messi is growing increasingly frustrated with Dembele - and wants him sold at the end of the season.
The Argentina international is Barcelona’s main man.
As a result, the Catalan giants often revolve their transfer plans around him in order to make sure he continues to shine.
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Barcelona news: Ousmane Dembele has been linked with Arsenal and Liverpool
Dembele was signed as a replacement for Neymar, who had a good relationship with Messi.
But Don Balon say Messi does not feel the same about Dembele, and a parting of the ways could be on the cards.
The forward is likely to find game time tougher to come by if, as expected, Barcelona wrap up a deal for Antoine Griezmann.
And Arsenal and Liverpool could be waiting for him with welcome arms.
The Gunners are a potential next destination for Dembele with Pierre-Emerick Aubameyang a possible pulling power.
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Barcelona news: Lionel Messi reportedly wants Ousmane Dembele sold this summer
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The Gabon international was close to the Barcelona star during their time at Dortmund together.
Liverpool, meanwhile, are still hunting for a Coutinho replacement.
Jurgen Klopp was Dembele’s landlord while the Barcelona star was strutting his stuff in the Bundesliga.
And they could make a move if the youngster becomes available.