Messi and Pique are among the most influential players at the Nou Camp and last summer were chosen as vice and fourth-captains to Andres Iniesta respectively.
It seems they're both keen to offer their take on Ernesto Valverde's team selections as Barcelona pursue glory on three fronts.
Valverde has used January signing Philippe Coutinho plenty of times since his arrival from Liverpool.
And while Messi and Pique might be pleased about that, the latest reports suggest the duo are questioning Mina's current status at Barcelona.
According to Spanish outlet Don Balon, Mina has quickly struck up friendships with Messi and Pique.
And they are apparently unable to understand the 'rudeness' that Valverde has shown towards him.
Mina's played just twice since linking up with Barcelona at the turn of the year.
And Valverde's decision to snub the 23-year-old has perplexed two of his senior team-mates.
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Lionel Messi and Gerard Pique are unhappy about Ernesto Valverde's treatment of Yerry Mina
Messi scores sensational goals in Barcelona training
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Ernesto Valverde has picked Yerry Mina just once since the 23-year-old joined Barcelona in January
Messi and Pique are said to believe Mina has shown enough in training to be afforded more opportunites.
And they want him to play more so he can exhibit that quality and gain the confidence needed to succeed at Barcelona.
La Liga leaders Barcelona play host to second-placed Atletico Madrid tomorrow.
And Valverde could be under pressure from Messi and Pique to include Mina in his plans for the game.