Wayne Rooney returns to the bench for Louis van Gaal's side
Marouane Fellaini and Ander Herrera replace Morgan Schneiderlin and Juan Mata, while Wayne Rooney returns to the bench after two months out with a knee injury.
Timothy Fosu-Mensah, who was injured in Sunday's loss at Tottenham, is fit to start.
West Ham have also made two changes, with Darren Randolph and Enner Valencia replacing Adrian and Winston Reid.
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