Cuadrado completed a £26.1m switch to the Blues on deadline day which undeniably showed a statement of intent on Jose Mourinho's part.
However, according to reports, Cuadrado's potential debut has been offset by news of a setback for Fabregas.
The Daily Telegraph suggests Fabregas is struggling to shake off a hamstring injury and could be out for a further two games.
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Juan Cuadrado could make his Chelsea debut against Aston Villa
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It is thought that Mourinho isn't prepared to take a gamble on Fabregas' fitness with a crucial Champions League tie against Paris Saint-Germain on the horizon.
The Blues are already without top score Diego Costa, who is currently serving a three-match suspension.
Added to that, Ramires has only just returned to full fitness and could retain his place if Fabregas misses the Villa and Everton clashes.