According to Spanish reports, Chelsea will go toe-to-toe with Barcelona for the highly-rated attacking midfielder next summer.
Jose Mourinho has long admired the technical ability of Koke, and will consider meeting the playmakers' sizeable £48million release clause to lure him to Stamford Bridge.
He would join compatriots Cesc Fabregas, Diego Costa and Cesar Azpilicueta who are set to provide the backbone of Mourinho's illustrious squad for many years to come.
Chelsea's decision to target Koke may be a result of the many potential suitors of Borussia Dortmund midfielder Marco Reus.
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Eden Hazard is fit and available for Chelsea's clash with Southampton
Khedira's future has been one of the years longest running transfer sagas, but looks set to be decided in the coming weeks.
Arsenal, Manchester United and Bayern Munich will provide the most competition for his signature, with the latter believed to be favourites.
The 27-year-old has made precious few appearances this campaign, and may be destined to leave the Bernabeu.
Sami Khedira Player Profile
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Chelsea manager Jose Mourinho could rest Belgian star Eden Hazard for Sunday's trip to Southampton.
Hazard was unlikely to feature against West Ham, but prevailed only to suffer another knock during the Boxing Day clash.
Reports suggest the 23-year-old will be given a chance to prepare for the Blues' New Year's Day London derby with Tottenham.
Andre Schurrle is the most likely candidate to replace the in-form Hazard.