Spurs left-back Sergio Reguilon and captain Harry Kane ran to referee Andre Marriner while team-mates Eric Dier and Oliver Skipp told medics.
All players were ordered off the pitch by Mr Marriner just before half-time.
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Newcastle later confirmed the fan had been stabilised and taken to hospital.
The medics at St James' Park were given a round of applause as the game resumed 12 minutes later.
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Sky Sports pundit David Ginola, who suffered a heart attack during a game in 2016, outlined the importance of defibrillators in stadiums. He said: "It is vital I hope the man or the woman is going to be fine."
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