Bernd Leno might play again later this season (Image: GETTY)
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In contrast, the Saints enjoyed a comfortable 3-0 win over Norwich, but Hasenhuttl insists Arsenal are still a dangerous side despite their problems.
"He has a strong team - it's never or a good moment [to play them]," Hasenhuttl said.
"It's always difficult because they have quality, they have fantastic players and it's always to play the game.
"Even if they have a few injuries, the quality is so big they can absolutely hit back immediately and if you give them a little space, they are unstoppable with their speed.
"We must really take care, really pay attention of everything and finally make it a very good game."
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