Paul Pogba doesn't make the starting line up as Mourinho makes wholesale changes to the side that lost to Valencia in the Champions League on Wednesday.
Nemanja Matic and Ander Herrera are preferred in midfield while Romelu Lukaku keeps his place from midweek ahead of the returning Anthony Martial.
Marcus Rashford also makes the side while Victor Lindelof returns from injury to start along side Chris Smalling at the back.
Matteo Darmian and Diego Dalot provide support as full-backs while Ashley Young and Jesse Lingard also start.
Klopp will be looking for his first Anfield win over United (Image: GETTY )
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Van Dijk has been imperious this season for Liverpool (Image: GETTY )
Man Utd starting XI: De Gea, Dalot, Smalling, Lindelof, Darmian, Young, Herrera, Matic, Lingard, Rashford, Lukaku
Man Utd subs: Romero, Bailly, Valencia, Fellaini, Pogba, Martial, Mata
Liverpool starting XI: Alisson, Clyne, Lovren, Van Dijk, Robertson, Fabinho, Wijnaldum, Keita, Mane, Salah, Firmino
Liverpool subs: Mignolet, Henderson, Sturridge, Moreno, Lallana, Shaqiri, Camacho