BBC Sport pundit Chris Sutton believes Kane has suffered ankle ligament damage again.
He said: "That is a massive blow for Spurs - to lose their king, their main man.
"It's the way he lands on his left foot.
"He makes the challenge and then his ankle rocks, which would suggest ligament damage."
Harry Kane injured: The Tottenham star could be out for the season (Image: GETTY)
Harry Kane receives an MBE for services to football
Harry Kane could be out for the rest of the season (Image: GETTY)
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Tottenham fans were raging at the incident and believe Kane could now be out for the season.
One said: “Tottenhams season over Harry Kane injured again.”
Another added: “@HKane needs to forget about the rest of the season including the nations league and rest that ankle fully before he ends his career to short.”
A third explained: “Harry Kane is always rushing his recovery. It's catching up to him now.”
Harry Kane was injured in a collision with Man City star Fabian Delph (Image: GETTY)