It wasn’t all bad news for United, though, as both Alexis Sanchez and Marcus Rashford returned to training.
Sanchez has missed the last five weeks with a hamstring injury but looked fit as a fiddle during the training session.
Rashford, who missed United’s 2-1 defeat to Wolves due with an ankle problem, also returned to the fold after some light running and stretching with one of the club's physios.
United manager Ole Gunnar Solskjaer is hoping to be able to call on Matic tomorrow but is resigned to being without the services of Herrera, Valencia and Bailly.
Man Utd Injury News: Four of Ole Gunnar Solskjaer's Man Utd players missed training on Tuesday (Image: GETTY)
Man Utd Injury News: Solskjaer will be without the services of three first-team players tomorrow (Image: GETTY)
Antonio [Valencia] and Eric [Bailly] definitely out
Ole Gunnar Solskjaer on United's injury crisis
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Speaking in his pre-match press conference on Tuesday, he said: “Uhmm, we still hope that maybe Nemanja can be ready.
“And Ander probably out. Antonio and Eric definitely out.”
When pressed on why Rashford trained alone before joining in with his team-mates, Solskjaer said: “He needed the extra warm up, hopefully he won’t get a reaction.
“He couldn’t join the boxes which is the fun part of training, let’s see tomorrow, hopefully he will be ready.”