Osteoarthritis of the knee: THIS gender is more likely to suffer from the joint condition
Osteoarthritis, also known as ‘wear and tear’ arthritis, commonly affects the largest joint in the body - the knee.
Osteoarthritis of the knee: It affects more women than men
Over a lifetime knees have to withstand a lot of stress, according to Arthritis Research UK.
They are essential for locking us into position so we can stand upright, and act as a hinge when we walk.
In the UK, osteoarthritis of the knee affects 8.75 million people.
However a new study has discovered why it affects women more than men.
Largest joint: Knees have to withstand a lot of stress over a lifetime
The researchers discovered there are differences between males and females in the messages cells are sending and receiving within the fluid in the knee.
Researchers at the Medical College of Georgia at Augusta University have found the reason for the gender difference is in the fluid the knee holds.
This synovial fluid is there to help protect the cartilage which provides padding between our bones.
They discovered there are differences between males and females in the messages cells are sending and receiving within the fluid.
The study authors believe this is why the disease presents itself more in women than in men.
Gender diffeences: It's thought to be down to oestrogen levels
Osteoarthritis is a destruction of cartilage, and a common sign of ageing.
The researchers believe the new findings may help provide a way to provide more targeted diagnosis and treatment.
Currently treatment seeks to relieve inflammation and pain symptoms, and may involve a knee replacement.
In the study, the authors built on previous knowledge that synovial fluid could provide clues about joint health, and looked at traveling compartments in the fluid called exosomes.
Ruby's story of living with osteoarthritis
Whole body: Osteoarthriti can also affect other joints such as those in the hands
The researchers discovered gender differences in exosome content.
They believe these are due to oestrogen levels changing in women.
Lower oestrogen levels, like those that occur following menopause, trigger production of more cells that destroy bone.
Osteoarthritis also affects other areas of the body, including the hips and hands.